Table 2.

A table demonstrating further information on the genetic variants investigated in this study. All variants listed here have previously been associated directly with RAS, indirectly with RAS (vitamin D-metabolising system), or with forms of pancreatic disease. Allele frequencies are based on Caucasian data from HapMap and ABI AoD.

Gene	Gene Symbol	Chrom Location	SNP Name	ID Number	DNA Change	Allele Frequencies	Known Effect
Angiotensin Converting Enzyme 1	ACE	17q23.3	I/D	rs4646994	----------------	0.54D:0.46I	D Allele: Higher Levels of Tissue & Circulating ACE56
Angiotensin II Receptor Type 1	ATR1	3q24	A1166C	rs5186	A>C	0.75A/0.25C	C Allele: Increased Receptor Activity57,58
Angiotensin II Receptor Type 2	ATR2	Xq23	1675	rs1403543	G>A	0.61A:0.39G	G Allele: Increased Receptor Expression57
Angiotensinogen	AGT	1q42.2	M235T	rs699	C>T	0.62T:0.38C	T Allele: Higher Levels of AGT, Low Prorenin, Susceptibility to DM59
Renin	REN	1q32	----------------	rs5707	G>T	T0.87:G0.13	G Allele: Increased Levels of Renin60
Vitamin D Receptor	VDR	12q13.11	FokI	rs2228570	C>T	0.56C:0.44T	T Allele: Increased Suceptibility to DM61
Vitamin D Hydoroxylase	CYP2R1	11p15.2	CYP2R1	rs10741657	A>G	0.63G/0.37A	G Allele: Increased Susceptibility to DM62
Vitamin D Binding Protein	GC	4q12	----------------	rs7041	G>T	0.58G:0.43T	1S & 1S-2: Increased Levels of Circulating Vitamin D Levels63,64

SNP- Single Nucleotide Polymorphism; Chrom- Chromosome; DM- Diabetes Mellitus