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. 2014 Oct 10;8:1827–1837. doi: 10.2147/DDDT.S67961

Figure 6.

Figure 6

Effects of MK-2206 on tumor growth of human CNE-2 xenografts in nude mice.

Notes: (A) The treatments began on day 1 after grouping (day 0), including 30% Captisol 10 mL/kg once a week, MK-2206 480 mg/kg once a week, and MK-2206 240 mg/kg three times a week for 2 weeks. During treatment, tumor volumes were measured every other day. Points, mean of tumors; bars, standard deviation. #P<0.05 compared with vehicle control; *P<0.01 compared with vehicle control. (B) After 18 days of grouping, the mice were killed and the tumors were removed and weighed. *P<0.01 compared with vehicle control. (C) Body weight was measured every other day and used to assess toxicity of treatment. (D) Tumors were resected, fixed, and paraffin embedded. The sections were analyzed by hematoxylin-eosin (HE) staining and by immunohistochemistry, using p-PRAS40 and p-S6 antibodies. The representative photographs in tumor sections are shown (×400).

Abbreviations: tiw, three times per week; qw, once a week; PRAS40, proline-rich-Akt substrate, 40kDA.