Table 3.
Associations of potential confounders with body mass index and genetic risk score among population controls (= 2169)
| Variables | Body mass index | P * | Unweighted genetic risk score | Weighted genetic risk score | P * | |
|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | P * | Mean (SD) | |||
| Age, β on linear regression | -0.0279 (-0.046, -0.010) | .002 | 0.0032 (-0.010, 0.017) | .64 | 0.0008 (-0.001, 0.003) | .45 |
| Sex | .78 | .88 | .66 | |||
| Male | 27.02 (4.39) | 26.53 (3.46) | 3.73 (0.55) | |||
| Female | 26.95 (5.62) | 26.56 (3.73) | 3.72 (0.53) | |||
| Highest level of education | .48 | .04 | .02 | |||
| Less than high school | 27.14 (4.95) | 26.83 (3.45) | 3.77 (0.51) | |||
| High school or more | 26.97 (4.60) | 26.46 (3.54) | 3.71 (0.54) | |||
| Missing | 26.42 (4.24) | 25.25 (3.20) | 3.53 (0.49) | |||
| Cumulative smoking history, pack-years | .08 | .35 | .52 | |||
| Never smoker | 26.88 (4.51) | 26.37 (3.44) | 3.71 (0.53) | |||
| ≤15 | 26.62 (4.53) | 26.75 (3.40) | 3.76 (0.52) | |||
| 15.01–30 | 27.45 (4.59) | 26.65 (3.56) | 3.72 (0.53) | |||
| 30.01–50 | 27.03 (4.97) | 26.54 (3.72) | 3.74 (0.55) | |||
| >50 | 27.44 (5.12) | 26.74 (3.64) | 3.74 (0.58) | |||
| Missing | 27.07 (5.04) | 26.21 (3.81) | 3.67 (0.58) | |||
| Frequency of heartburn / acid reflux | <.001 | .28 | .79 | |||
| Never | 26.46 (4.30) | 26.63 (3.50) | 3.73 (0.53) | |||
| Ever | 27.32 (4.85) | 26.46 (3.57) | 3.72 (0.55) | |||
| Missing | 28.81 (5.45) | 26.67 (3.20) | 3.72 (0.49) | |||
| Frequency of use of aspirin or non-aspirin NSAIDs | .002 | .02 | .07 | |||
| Never | 26.53 (4.29) | 26.36 (3.45) | 3.70 (0.53) | |||
| Ever | 27.19 (4.69) | 26.73 (3.53) | 3.74 (0.53) | |||
| Missing | 27.58 (5.41) | 26.40 (3.65) | 3.74 (0.56) | |||
| Ever use of acid suppressant medications | <.001 | .94 | .71 | |||
| Never | 26.90 (4.63) | 26.54 (3.51) | 3.72 (0.54) | |||
| Ever | 28.40 (5.25) | 26.55 (3.56) | 3.73 (0.53) | |||
| Missing | 25.94 (3.80) | 26.52 (3.54) | 3.74 (0.52) |
* P value from Student t test or analysis of variance. Missing categories were excluded from comparison tests. NSAIDs = nonsteroidal anti-inflammatory drugs.