Table 3.
Correlation coefficient and rate constant for in vitro release of isoniazid from Mg/Al-LDHs
| Samples | pH | % release |
R2
|
Pseudo second order
|
||
|---|---|---|---|---|---|---|
| Pseudo first order | Pseudo second order | Parabolic diffusion model | Rate constant K (mg/min) | |||
| Nanocomposite A | 4.80 | 96.00 | 0.72 | 0.99 | 0.62 | 5.31×10−5 |
| Nanocomposite A | 7.40 | 85.00 | 0.70 | 0.99 | 0.44 | 1.02×10−5 |
| Nanocomposite B | 4.80 | 90.00 | 0.94 | 0.99 | 0.58 | 7.80×10−5 |
| Nanocomposite B | 7.40 | 85.00 | 0.76 | 0.99 | 0.85 | 2.81×10−5 |
Notes: Correlation coefficient (R2), and rate constants (K) obtained by fitting the data of the release kinetics of isoniazid from nanocomposites A and B into phosphate buffered solution at pH 4.8 and 7.4.
Abbreviation: LDHs, layered double hydroxides.