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. 2014 Oct 2;141(2):493–504. doi: 10.1093/toxsci/kfu140

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© The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

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FIG. 5. — Effects of an acute change in volemia on CgH₂S. (A) Recording during withdrawal (W) or infusion (I) of 2 ml of blood before and after infusing 2 ml of MetHb solution. Respiratory flow (), alveolar fraction of H₂S (FAH₂S), and additional air flow (_add) signals are shown. (B) Effect of blood versus MetHb infusion on mean CgH₂S, th esymbol B related the basleine values before withdrawal (W) or infusion (I) of blood. (C) Change in CgH₂S after withdrawal or infusion of blood or MetHb compared with values obtained before each treatment. Withdrawing and infusing blood produced a small rise and decrease in CdH₂S, respectively. Infusing MetHb, instead of blood, produced a dramatic decrease in CgH₂S (p < 0.01) that persisted, and in most cases prevented, any other effects of volemia on CgH₂S. *Significantly different at p < 0.05, **Significantly different at p < 0.01.

Inline graphic — Effects of an acute change in volemia on CgH₂S. (A) Recording during withdrawal (W) or infusion (I) of 2 ml of blood before and after infusing 2 ml of MetHb solution. Respiratory flow (), alveolar fraction of H₂S (FAH₂S), and additional air flow (_add) signals are shown. (B) Effect of blood versus MetHb infusion on mean CgH₂S, th esymbol B related the basleine values before withdrawal (W) or infusion (I) of blood. (C) Change in CgH₂S after withdrawal or infusion of blood or MetHb compared with values obtained before each treatment. Withdrawing and infusing blood produced a small rise and decrease in CdH₂S, respectively. Infusing MetHb, instead of blood, produced a dramatic decrease in CgH₂S (p < 0.01) that persisted, and in most cases prevented, any other effects of volemia on CgH₂S. *Significantly different at p < 0.05, **Significantly different at p < 0.01.