Table 1.

Association of a focused set of candidate single nucleotide polymorphisms with blood pressure phenotypes

Index SNP	Chr	Position	Genes	WGHS						ICBP
				A1/A2	A1F	Genotype	BP phenotype	Beta (SE)	P valuea	P value
rs17467825	4	72824381	GC	G/A	0.28	Imputed	SBP	−0.11 (0.21)	0.61	0.45
							DBP	−0.11 (0.14)	0.42	0.60
							MAP	−0.13 (0.16)	0.41
							PP	−0.07 (0.12)	0.56
rs12785878	11	70845097	DHCR7	G/T	0.25	Imputed	SBP	0.068 (0.21)	0.75	0.70
							DBP	−0.081 (0.14)	0.56	0.12
							MAP	−0.029 (0.16)	0.86
							PP	0.14 (0.12)	0.25
rs1544410	12	46526102	VDR	T/C	0.41	Imputed	SBP	0.052 (0.19)	0.78	0.50
							DBP	−0.037 (0.12)	0.77	0.89
							MAP	−0.0025 (0.14)	0.99
							PP	0.091 (0.11)	0.41
rs10735810	12	46559161	VDR	A/G	0.38	Genotyped	SBP	0.055 (0.19)	0.77	NA
							DBP	0.00096 (0.13)	0.99	NA
							MAP	−0.0059 (0.14)	0.97
							PP	0.054 (0.11)	0.63
rs11568820	12	46588812	VDR	T/C	0.20	Imputed	SBP	0.067 (0.23)	0.77	0.34
							DBP	0.0034 (0.15)	0.98	0.97
							MAP	0.022 (0.18)	0.90
							PP	−0.018 (0.13)	0.90

Candidate SNPs selected for analysis have previously shown significant associations with blood pressure (BP) or other disorders with material BP change. In the Women’s Genome Health Study (WGHS), analysis was adjusted for age at randomization and population stratification; data presented are effect size beta (SE) in millimeters of mercury per coded allele; all imputation r ² > 0.80. In the International Consortium of Blood Pressure (ICBP), P for single nucleotide polymorphisms (SNPs) presented are genome-wide meta-analysis P values after correction for genomic control.

Abbreviations: A1, coded allele; A2, noncoded allele; A1F, coded allele frequency; Chr, chromosome; DBP, diastolic blood pressure; MAP, mean arterial pressure; NA, not available; PP, pulse pressure; SBP, systolic blood pressure.

^aNominal P value.