Table 4.

Association of vitamin D pathway genes with blood pressure observed in the International Consortium of Blood Pressure

Gene	Chr.	ICBP					WGHS
		BP phenotype	Gene-based P value a	Best SNP	Position	P value for SNP	Genotype	A1/A2	A1F	Beta (SE)	P valueb
NCOR1	17
		DBP	0.017	rs2157990	15902718	0.005	Imputed	T/A	0.43	−0.17 (0.19)	0.36
TP53BP1	15
		SBP	0.018	rs12899865	41528309	0.0004	Imputed	A/G	0.18	−0.027 (0.24)	0.91
		DBP	0.031	rs16957715	41496029	0.005	Imputed	G/T	0.19	−0.027 (0.23)	0.91
TYRP1	9
		SBP	0.00083	rs10960738	12638831	9.87×10–5	Imputed	C/A	0.31	0.11 (0.20)	0.59

Table shows the genes that had association with systolic blood pressure (SBP) or diastolic blood pressure (DBP) in the International Consortium of Blood Pressure (ICBP) at gene-based P value <0.05 and their replication in the Women’s Genome Health Study (WGHS). In the ICBP, P for single nucleotide polymorphisms (SNPs) presented are genome-wide meta-analysis P values after correction for genomic control. In the WGHS, analysis was adjusted for age at randomization and population stratification; data presented are effect size beta (SE) in millimeters of mercury per coded allele; all imputation r ² > 0.80.

Abbreviations: A1, coded allele; A2, noncoded allele; A1F, coded allele frequency; BP, blood pressure; Chr., chromosome.

^aCorrections for multiple testing were performed by using a versatile gene-based association study.

^bNominal P value.