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Schematic representation of functional domains and mutations of ANTXR1.
(A) Mutation hotspot in ANTXR1 is in the anthrax-binding domain. Other mutations, Arg250His (MSS), Pro430Leu (MSS) and Arg480Cys (MSI) are all located in the same functional domain. (B) The hotspot amino acid is depicted with the black arrow in the multispecies comparison (ClustalW2) and is highly conserved between species.
