Figure 2.

Recombinant α-galactosidase contains only “unedited” peptide sequence. A, Schematic representation of the editing site of human α-gal A mRNA and the resulting amino acid change. B, Full mass spectrum of agalsidase β. The X-axis indicates mass/charge values (m/z); the Y-axis indicates the relative intensity of detected ions (%). Identified peptides derived from α-gal A are indicated with their mass value. C, Enlargement of the 1,130–1,330 m/z range of panel B, with the isotopic distribution around the m/z 1,158.54 and 1,286.64 peaks. X-axis and Y-axis as in panel B.