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. 2014 Aug 6;34(32):10475–10487. doi: 10.1523/JNEUROSCI.1793-14.2014

Figure 3.

Figure 3.

Hyperplasia in the developing neocortex of Afadin-cKO mice. Overview of the developing neocortex from control and Afadin-cKO at E13.5 and E16.5 stained with the nuclear marker DAPI (A–F), the proliferation marker Ki67 (B–G), the radial glia cell marker Pax6 (C–H), the intermediate progenitor marker Tbr2 (D–I), and the neuronal marker Tuj-1 (E–J). Note the general disorganization of the cortical cells and axon bundles in the mutant mice. The increased size of the cortex in the Afadin-cKO mice is visible at E13.5 and E16.5. Scale bars, 100 μm. CP, Cortical plate; IZ, intermediate zone.