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. 2014 Aug 6;34(32):10582–10591. doi: 10.1523/JNEUROSCI.1912-14.2014

Figure 7.

Figure 7.

GJs formed by Cx36-mediated bystander cell death under excitotoxic conditions. A–D, Neuronal death was measured by EthD staining in whole-mount retinas of Het, Cx36−/−, Cx36−/−/45−/− dKO, and Cx45−/− mice. E, Histogram quantifying excitotoxic cell death in the GCL of retinas from Het and connexin KO mice. Compared with Hets (n = 35/n = 3), the reduction in NMDA-induced cell death was statistically significant in retinas of Cx36−/− (n = 35/n = 3), and Cx36−/−/Cx45−/− dKO (n = 13/n = 3) mice, but not in Cx45−/− (n = 17/n = 3; p > 0.1). **p < 0.001 versus Het. Scale bar, 50 μm.