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MiR-188 targets multiple genes involved in G 1 /S cell cycle transition. MiR-188 suppresses cyclin D/CDK4, cyclin E/CDK2 and cyclin A/CDK2 activity by directly targeting their 3′UTRs. MiR-188 mediated downregulation of G1/S CDKs suppresses Rb phosphorylation and E2F transcriptional activity, and finally leads to G1/S cell cycle arrest and growth inhibition.
