Table 1.
Genes Preferentially Expressed in the Inner Ear with a Cy3/Cy5 Ratio of >10
| Cy3/Cy5 Ratio in |
|||||
| GenBankAccessionNo. | Cochlea | Vestibule | Description | Locus | Correspondence with Deafness Locus |
| AA669336 | 156.51 | 136.15 | Coagulation factor C homology (cochlin, COCH) | 14q12-q13 | |
| L02950 | 119.55 | 59.74 | μ-crystallin (CRYM) | 16p13.11-p12.3 | |
| M61901 | 114.30 | 70.40 | Prostaglandin D synthase | 9q34.2-34.3 | DFNB33 (9q34.3) |
| NM_020157 | 79.87 | 27.51 | Otoraplin | 20p12.1-p11.23 | Cochlear genea |
| NM_003460 | 77.36 | 185.57 | Zona pellucida glycoprotein 2 (sperm receptor) | 16p12 | |
| M64722 | 69.52 | 104.29 | clusterin (TRPM-2, apolipoprotein J) | 8p21-p12 | |
| J02611 | 68.59 | 108.76 | Apolipoprotein D | 3q26.2-qter | |
| XM_051860 | 56.54 | 22.55 | KIAA1199 protein | 15q24 | |
| W39428 | 55.10 | 67.96 | F-box only protein 2 | 1p36.23 | |
| AA972852 | 43.41 | 45.94 | Retinol-binding protein 1, cellular | 3q23 | DFNB15 (3q21-25/19p13) |
| J05096 | 41.98 | 55.99 | ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide | 1q21-q23 | DFNA7 (1q21-q23) |
| AA252389 | 38.77 | 54.70 | Lipoma HMGIC fusion partner | 13q12 | |
| AA292179 | 37.41 | 16.65 | Ubiquitin A-52 residue ribosomal protein fusion product 1 | 19p13.1-p12 | DFNB15 (3q21-25/19p13) |
| M62402 | 30.46 | 44.97 | Insulin-like growth factor binding protein 6 | 12q13 | |
| AF039699 | 30.22 | 22.61 | USH1C | 11p14.3 | |
| X99920 | 26.20 | 70.30 | S100 calcium-binding protein A13 | 1q21 | DFNA7 (1q21-q23) |
| U59832 | 26.04 | 13.68 | Forkhead box D1 | 5q12-q13 | |
| X53331 | 23.79 | 16.19 | Matrix Gla protein | 12p13.1-p12.3 | |
| J02984 | 21.92 | 10.26 | Ribosomal protein S15 | 19p-tel | |
| X06617 | 20.19 | 17.83 | Ribosomal protein S11 | 19q13.3 | DFNA4 (19q13) |
| X75450 | 18.48 | 19.39 | Melanoma inhibitory activity (SH3 domain+) | 19q13.32-q13.33 | DFNA4 (19q13) |
| AA308743 | 17.91 | 11.85 | Ribosomal protein L35 | 9q34.1 | |
| AA526377 | 17.90 | 10.60 | Ribosomal protein L15 | 19q13.3 | DFNA4 (19q13) |
| AA496786 | 17.64 | 33.33 | Collagen, type IX, alpha 3 | 20q13.3 | |
| X96484 | 16.42 | 11.71 | DiGeorge syndrome critical region gene 6 | 22q11.21 | |
| AA058578 | 16.00 | 46.30 | Homo sapiens cDNA FLJ10158 fis | 3q12.3-21.3 | DFNB15 (3q21-25/19p13) |
| U14970 | 15.76 | 12.25 | Ribosomal protein S5 | 19q13.4 | DFNA4 (19q13) |
| AF052685 | 15.27 | 10.71 | Protocadherin gamma subfamily C, 3 | 5q32 | |
| F22593 | 15.27 | 34.13 | Vesicle-associated membrane protein 5 (myobrevin) | 2p11.2 | |
| W73992 | 15.15 | 11.10 | Serologically defined colon cancer antigen 43 | 9q22.2 | |
| AA633908 | 15.00 | 11.10 | ESTs | 20p12 | |
| X03342 | 14.89 | 15.31 | Ribosomal protein L32 | 3q13.3-q21 | |
| AA205528 | 14.79 | 14.90 | Carbonic anhydrase XIV | 1q21 | DFNA7 (1q21-q23) |
| AI344213 | 14.28 | 21.21 | Copper chaperone for superoxide dismutase | 11q13 | |
| AA057243 | 13.00 | 10.90 | PH domain containing protein in retina 1 | 11q13.5-q14.1 | |
| AA434038 | 12.96 | 11.83 | Gap junction protein, beta 2, 26kD (connexin 26) | 13q11-q12 | |
| AA148265 | 12.60 | 12.00 | Ribosomal protein L21 | 13q12.13 | |
| W84565 | 12.50 | 10.60 | Secreted protein of unknown function | 1q32.3 | |
| AI268685 | 12.33 | 11.38 | HSPC023 protein | 19p13.13 | DFNB15 (3q21-25/19p13) |
| AY043487 | 12.22 | 29.28 | Selenoprotein SelM (SELM) | 22q12 | |
| S72043 | 11.95 | 13.10 | Metallothionein 3 (growth inhibitory factor [neurotrophic]) | 16q13 | |
| AF284751 | 11.90 | 12.00 | Hypothetical protein HT036 | 1q34.1 | |
| X54412 | 11.88 | 35.98 | Collagen, type IX, alpha 1 | 6q12-q14 | |
| T55019 | 11.83 | 17.47 | Ribosomal protein L28 | 19q13.4 | DFNA4 (19q13) |
| AB003184 | 11.60 | 30.36 | Immunoglobulin superfamily containing leucine-rich repeat | 15q23-q24 | |
| X89401 | 11.43 | 20.16 | Ribosomal protein L21 | 13q12.13 | |
| AA625532 | 11.37 | 14.36 | Discoidin domain receptor family, member 2 | 1q12-q23 | DFNA7 (1q21-q23) |
| M68864 | 10.88 | 16.00 | ORF | 11cen-q12.1 | |
| AI240945 | 10.60 | 13.80 | Ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome | Yq11 | |
| AA446913 | 10.51 | 13.71 | Ubiquitin specific protease 11 | Xp21.2-p11.2 | |
| N71750 | 10.46 | 26.54 | Zinc-finger protein 288(BC015587) | 3q13 | |
| X13916 | 10.31 | 17.43 | Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 12q13-q14 | |
a
Otoraplin (OTOR [MIM 606067]) has been identified from a human fetal cochlear. So far, there is no report for human deafness-causing mutation. Abbreviations: DFNA, autosomal dominant loci; DFNB, autosomal recessive loci.