Table 1.
Replication Study Showing Allele Frequencies for Markers and Haplotypes within and Upstream of the NRG1 Gene
|
Frequency(%) |
|||||||||
| Scotland |
Iceland |
||||||||
| Marker | Allelea | ControlIndividualsb | Patientsb | P | RelativeRisk | ControlIndividualsb | Patientsb | P | RelativeRisk |
| Seven-marker haplotype | 5.9 (618) | 10.2 (609) | .00031 | 1.8 | 7.6 (394) | 14.4 (402) | .000087 | 2.1 | |
| Five-marker SNP | 27.4 (593) | 35.4 (596) | .000032 | 1.5 | 25.1 (394) | 32.1 (402) | .0018 | 1.4 | |
| SNP8NRG221132 | G (2) | 89.4 (526) | 90.9 (574) | .13 | 1.2 | 88.0 (252) | 90.0 (366) | .14 | 1.2 |
| SNP8NRG221533 | C (1) | 30.6 (515) | 38.4 (573) | .000064 | 1.4 | 29.7 (386) | 36.4 (370) | .0028 | 1.4 |
| SNP8NRG241930 | G (2) | 60.9 (561) | 66.6 (577) | .0021 | 1.3 | 65.7 (315) | 68.3 (367) | .16 | 1.1 |
| SNP8NRG243177 | T (3) | 35.8 (514) | 42.4 (568) | .00080 | 1.3 | 33.3 (108) | 38.9 (321) | .069 | 1.3 |
| SNP8NRG433E1006 | G (2) | 88.4 (290) | 89.2 (301) | .34 | 1.1 | 85.5 (259) | 87.3 (366) | .18 | 1.2 |
| 478B14-848 | 0 | 31.8 (588) | 32.8 (596) | .30 | 1.1 | 35.9 (294) | 37.5 (340) | .27 | 1.1 |
| 420M9-1395 | 0 | 41.2 (541) | 42.5 (587) | .27 | 1.1 | 45.3 (290) | 47.3 (350) | .24 | 1.1 |
a
Numeric values for SNP alleles shown within parenthesis are the same as those given in Stefansson et al. 2002.
b
Number of genotyped individuals for each marker is given in parenthesis.