. 2014 Oct 6;6(3):254–261. doi: 10.5114/jcb.2014.45757

Table 2.

Cause-specific (prostate cancer) survival, bPFS, and overall survival of all patients

Continuous variables	Cause-specific survival				bPFS				Overall survival
	Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate
	p	SHR	p	SHR	p	SHR	p	SHR	p	HR	p	HR
Age at implant (y)	0.787				0.775				< 0.001	1.097	< 0.001	1.098
PSA	< 0.001	1.041	0.597		< 0.001	1.052	0.004	1.025	0.132
Gleason score	< 0.001	2.830	0.027	2.105	< 0.001	1.888	0.650		< 0.001	1.211	0.701
Percent pos. biopsies	< 0.001	1.031	0.086		< 0.001	1.024	< 0.001	1.018	< 0.001	1.007	0.011	1.005
BMI	0.522				0.648				0.094
ADT duration	0.073				0.348				0.008	1.164	0.530
%D₉₀	0.713				0.421				0.421
Categorical variables
Metformin	< 0.001				0.624				< 0.001		0.006
Non-diabetic vs. diabetic without metformin	0.8451								< 0.001	1.997	0.002	1.567
Non-diabetic vs. diabetic with metformin	< 0.001	^*							0.834		0.873
BMI^*	< 0.001				< 0.001				< 0.001		< 0.001
Normal vs. underweight	< 0.001	^*			< 0.001	^*			< 0.001	4.363	0.003	3.526
Normal vs. overweight	0.654				0.817				0.001	0.705	0.027	0.791
Normal vs. obese class I	0.721				0.745				0.001	0.643	0.092
Normal vs. obese class 2+	0.406				0.693				0.587		0.216
XRT	0.006	4.507	0.958		< 0.001	2.594	0.152		0.024	1.213	0.799
ADT	0.252				0.866				0.029	1.208	0.839
Risk	< 0.001				< 0.001				< 0.001		0.042
Low vs intermediate	0.095		0.804		< 0.001	4.068	0.001	3.890	0.046	1.028	0.149
Low vs. high	< 0.001	18.944	0.739		< 0.001	9.554	0.002	8.387	< 0.001	1.743	0.356
Hypertension	0.005	0.216	0.015	0.156	0.455				0.026	1.206	0.483
Hypercholesterolemia	0.034	0.207	0.087		< 0.001	0.357	0.006	0.455	0.672
Cardiovascular disease	< 0.001	^*			0.014	0.383	0.060		< 0.001	1.762	0.001	1.433
Tobacco	0.0802				0.370				< 0.001		< 0.001
Never vs. former									< 0.001	1.451	0.001	1.396
Never vs. current									< 0.001	2.077	< 0.001	2.604
Perineural invasion	0.076				< 0.001	2.126	0.874		0.139

Approaching negative infinity (a result of no failures or deaths by the patients with the indicated condition). This variable was not included in multivariate analysis.

HR – hazard ratio, SHR – subdistribution hazard ratio, bPFS – biochemical progression-free survival, PSA – prostate-specific antigen, BMI – body mass index, ADT – adrogen deprivation therapy, XRT – external beam radiation therapy