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. 2014 Oct 14;7:146. doi: 10.1186/s13068-014-0146-2

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© Solli et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The methanogenesis pathway. Enzymes are shown in blue boxes. Subunits missing in all our datasets (R1, R2, R3, R4, and IN) after search against the KO database at MG-RASTare underlined. Abbreviations used in the figure are Acetyl-Pi: acetyl phosphate; ack: acetate kinase; acs: acetyl-CoA synthetase; cdh: acetyl-CoA decarbonylase/synthase; CO: carbon monoxide; CoA: coenzyme A; CoB: coenzyme B; CoB-S-S-CoM: coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide; F420: coenzyme F420; fmd: formylmethanofuran dehydrogenase; Formyl-H4MPT: 5-formyl-5,6,7,8-tetrahydromethanopterin; Formyl-MF: formylmethanofuran; frh: coenzyme F420 hydrogenase; ftr: formylmethanofuran-tetrahydromethanopterin N-formyltransferase; H4MPT: 5,6,7,8-tetrahydromethanopterin; hdr: heterodisulfide reductase; mch: methenyltetrahydromethanopterin cyclohydrolase; mcr: methyl-coenzyme M reductase; mer: 5,10-methylenetetrahydromethanopterin reductase; Methenyl-H4MPT: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin; Methyl-CoM: methylcoenzyme M; Methylene-H4MPT: 5,10-methylenetetrahydromethanopterin; Methyl-H4MPT: 5-methyl-5,6,7,8-tetrahydromethanopterin; mtd: methylenetetrahydromethanopterin dehydrogenase; mtr: tetrahydromethanopterin S-methyltransferase; ppa: inorganic diphosphatase; pta: phosphate acetyltransferase.