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. 2014 Oct 9;15(1):882. doi: 10.1186/1471-2164-15-882

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© Bohlin et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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dS / dN -based heatmap. The heatmap demonstrates a hierarchical cluster analysis of estimated dS/dN (the rate of synonymous to non-synonymous substitutions between taxa) of 1729 core genes from the 53 E. coli genomes. The differently colored labels designate phylogroups: D (light green), B2 (red), E (green), B1 (blue), and A (dark blue). Groups D, B2 and E consisted predominantly of pathogens; Group A was almost exclusively non-pathogenic, while Group B1 consisted of a mixture of pathogenic and non-pathogenic strains. The horizontal axis of the color key legend indicates multiples of dS to dN, where values close to 1 designates neutrality of selection.