FIGURE 7.

Effects of La³⁺ on I_SOC in normal (NCM460) and colon carcinoma (HT29) cells. I_SOC were activated by passive Ca²⁺ store depletion with extracellular thapsigargin (1 μm). For NCM460 cells, representative I-V relationships of I_SOC, in the absence and in the presence of 5 μm La³⁺ (A) and La³⁺-sensitive currents (B; n = 6). C, example of time course recordings of I_SOC that was further inhibited by La³⁺. D, average effect of La³⁺ on I_SOC in NCM460 cells, measured at −80 mV (mean ± S.E. of six independent experiments). F, *, p < 0.05. E–H, inhibition of I_SOC of HT29 cells by 5 μm La³⁺ (n = 10; *, p < 0.05).