Alignment of several IPMDH, Dml/TDH, TtuC, and NAD-dependent IDH proteins in the substrate recognition region
The numbers indicate the amino acid numbering of the first sequence from each group of enzymes. The conserved residues, identified as conserved motifs, are shown in boldface. The complete set of sequences used for the phylogenetic analysis and the alignment of the substrate recognition regions is provided in the supplemental material.