FIGURE 7.

Retinal degeneration and protein degradation in the light-exposed ARR1^−/− retina was prevented in the transducin (GNAT1) knock-out background. A, retinal morphology of ARR1^−/−GNAT1^−/− double knock-out mice was unchanged after light exposure. B, global protein ubiquitination (Ubi) levels, phototransduction, and GRP78 protein levels in ARR1^−/−GNAT1^−/− retinas did not change after light exposure. D, dark adapted; LD, 12 h light exposed followed by 36 h dark adaptation. C, the relative fold changes of phototransduction protein levels compared with dark-adapted control levels in ARR1^−/−GNAT1^−/− retinas (means ± S.E., n ≥ 3).