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Model of AIM2 inflammasome-induced IL-1β secretion. Poly(dA-dT)-induced IL-1β secretion depends on a series of signals, including the following: 1) the transcriptional regulation of IL-1β expression; 2) the EB1-mediated recruitment of the activated inflammasome, which induces maturation of IL-1β via caspase 1; and 3) the EB1-mediated delivery of inflammasome-containing autophagic vesicles.
