Fig. 3.

Loss of sEH prevents interstitial fibrosis induced by glomerulonephritis (GN). A: collagen deposition detected by Sirius red stain and α-SMA expression stained with α-SMA monoclonal antibody on kidney sections in WT or sEH-KO mice at 10 days after nonadministration or administration of anti-glomerular basement membrane (GBM) serum. Scale bars = 50 μm. B: percent of Sirius red-positive area on kidney sections. C: collagen content represented by hydroxyproline level in the kidneys. Error bars represent SD (n = 4). *P < 0.05 vs. sham. #P < 0.05 vs. WT. §P < 0.05 vs. 3 days.