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Loss of sEH reduces transforming growth factor (TGF)-β signaling during UUO. A: kidney TGF-β1 level in WT or sEH-KO mice after sham operation or UUO was measured by multiplex immunoassay. B: Smad3 phosphorylation (p-Smad3) in the kidneys was analyzed by Western blot. The bands were quantified using Lab Works analysis software. Error bars represent SD (n = 5). *P < 0.05 vs. sham. #P < 0.05 vs. WT. §P < 0.05 vs. 3 days.
