Fig. 7.

Pharmacological inhibition of sEH attenuates fibrotic and inflammatory protein expressions induced by UUO. A: profibrotic expression of α-SMA and fibronectin in sham or UUO kidneys of mice treated with or without trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (tAUCB), a sEH inhibitor, evaluated by Western blot analyses. B: proinflammatory expression of TNF-α and ICAM-1 in the kidneys evaluated by Western blot analyses. The bands were quantified using Lab Works analysis software. Error bars represent SD (n = 4). *P < 0.05 vs. sham. †P < 0.05 vs. vehicle.