Table 1.
Normal Na+ (0.15%) |
High Na+ (3.2%) |
Low Na+ (0.01%) |
||||
---|---|---|---|---|---|---|
KO | Floxed | KO | Floxed | KO | Floxed | |
Food, g/day | 9.3 ± 0.5 | 9.2 ± 0.2 | 9.0 ± 0.7 | 10.0 ± 0.3 | 11.4 ± 0.3 | 10.9 ± 0.3 |
Water, ml/day | 7.5 ± 0.6 | 6.9 ± 0.3 | 14.6 ± 1.2 | 16.1 ± 0.7 | 7.2 ± 0.7 | 7.9 ± 0.2 |
Weight, g | 29.8 ± 1.2 | 29.5 ± 1.1 | 30.0 ± 1.1 | 29.8 ± 1.0 | 31.7 ± 1.1 | 31.4 ± 0.8 |
UV, ml/day | 3.3 ± 0.2 | 3.7 ± 0.3 | 6.6 ± 0.6 | 7.2 ± 0.7 | 4.5 ± 0.3 | 4.5 ± 0.2 |
UNaV, μeq/day | 319 ± 24 | 340 ± 24 | 2,595 ± 256 | 2,827 ± 181 | 96 ± 13 | 89 ± 8 |
UKV, μeq/day | 289 ± 21 | 308 ± 24 | 575 ± 21 | 604 ± 14 | 573 ± 37 | 562 ± 21 |
Data are means ± SE. Food intake, water intake, weight, urine volume (UV), urinary Na+ excretion (UNaV), and urinary K+ excretion (UKV) are shown in collecting duct (CD) renin knockout (KO) and floxed mice. Data are shown on the third day after transitioning to each diet, n = 12 for both groups.