Table 3.
Hemodynamic renal responses of COX-2 inhibitor in rats infused with ANG II for 5–7 and 14 days
| ANG II Infusion (Days 5–7) |
ANG II Infusion (Day 14) |
|||
|---|---|---|---|---|
| Control | COX-2 inhibitor | Control | COX-2 inhibitor | |
| MABP, mmHg | 115 ± 4 | 110 ± 4 | 144 ± 7 | 118 ± 7* |
| GFR, μl·min−1·g−1 | 1.1 ± 0.1 | 0.8 ± 0.1* | 0.9 ± 0.1 | 0.6 ± 0.1* |
| RBF, ml/min | 6.3 ± 0.7 | 4.8 ± 0.5* | 8.1 ± 0.7 | 5.7 ± 0.5* |
| CBF, perfusion units | 568 ± 21 | 481 ± 29* | 647 ± 49 | 509 ± 26* |
| MBF, perfusion units | 166 ± 10 | 125 ± 17* | 217 ± 21 | 142 ± 12* |
| Urine flow, μl/min | 27 ± 5 | 18 ± 2* | 14 ± 2 | 11 ± 3* |
| Sodium excretion, μeq/min | 1.3 ± 0.5 | 0.8 ± 0.2 | 0.3 ± 0.1 | 0.2 ± 0.1 |
Values are means ± SE.
COX, cyclooxygenase; MABP, mean arterial blood pressure; GFR, glomerular filtration rate; RBF, renal blood flow; CBF, cortical blood flow; MBF, medullary blood flow.
*
P < 0.05 vs. control.