Fig. 5.

Loss of CaMKKα enhances functional overload-induced increases in skeletal muscle mass. Plantaris muscles from CaMKKα knockout mice and their wild-type littermates were stimulated to hypertrophy via unilateral functional overload (OVL). After 7 days, muscles were frozen and weighed. A: mouse body weights at the time of overload surgery. B: muscle frozen wet weight. C: ratio of mouse muscle weight to body weight. D: percent change in muscle weight in response to overload; n = 9–11 mice or muscles/group. P < 0.05 = * vs. sham, ^# vs. wild type.