Table 2.
Mouse, n = 6/group | GITT, min | Gastric Emptying, % | Small Bowel Transit, cm | Bead Expulsion, s |
---|---|---|---|---|
OTRKO vs. WT (C57BL/6) | ||||
WT | 160.3 ± 10 | 86.6 ± 8.9 | 3.8 ± 0.7 | 509 ± 73 |
OTRKO | 126.5 ± 5.3* | 92.1 ± 7.2 | 3.5 ± 0.9 | 1326 ± 312* |
Exogenous OT vs. saline in C57BL/6 mice | ||||
Saline | 87.3 ± 5.8 | 98.4 ± 0.4 | 3.8 ± 0.7 | 630 ± 116.7 |
OT | 115.0 ± 9.0† | 86.9 ± 2.8† | 4.0 ± 0.5 | 600 ± 73.5 |
Exogenous OT vs. saline in BALB/c mice | ||||
Saline | 83.8 ± 15.0 | 97.0 ± 0.9 | 3.9 ± 0.3 | 357.7 ± 108 |
OT | 185.3 ± 30.4† | 78.4 ± 5.8† | 2.7 ± 0.2† | 329.4 ± 80.5 |
Values are means ± SE.
OTRKO significantly different from WT.
OT significantly different from saline. GITT, gastrointestinal transit time.