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. 2014 Nov;28(11):4583–4590. doi: 10.1096/fj.13-243733

Figure 4.

Figure 4.

HUVEC culture geometry affects phenotypic behavior of 786-O cells. 786-O cells cocultured with HUVECs in the lumen geometry show a more elongated phenotype compared to 786-O cells in monoculture or in coculture with HUVECs in 2D or 3D. Scale bars = 100 μm. Insets: representative phalloidin-stained 786-O cells in each culture condition to better show morphology. Inset scale bars = 10 μm. Circularity of the 786-Os in coculture with HUVECs in the lumen geometry was statistically significant (P<0.005) compared to all other conditions, as determined by a Student's t test. Error bars = sd.