Table 1.
Amino acid sequences of the wild-type and mutants of the D1R C tail
| D1R C-tail | Sequence | Interaction with D2R |
|---|---|---|
| WT | SISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | Yes |
| C1 | SISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVS(LEKIQPITQNGQHPT) | Yes |
| C2 | SISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPA(LSVILDYDTDVSLEKIQPITQNGQHPT) | Yes |
| C3 | SISKECNLVYLIPHAVGSSEDLKKEEAA(GIARPLEKLSPA)LSVILDYDTDVSLEKIQPITQNGQHPT | Yes |
| C4 | SISKECNLVYLIPHAV(GSSEDLKKEEAA)GIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | No |
| C5 | SISKEC(NLVYLIPHAV)GSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | Yes |
| C6 | SISKECNLVYLIPHAV(GSSEDL)KKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | Yes |
| C7 | SISKECNLVYLIPHAVGSSEDL(KKEEAA)GIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | No |
| C8 | SISKECNLVYLIPHAVGSSEDLAAAAAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | No |
| C9 | SISKECNLVYLIPHAVGSSEDLKKAAAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | No |
The whole D1R C tail: MAFSTLLGCYRLCP—(86 aa)—TQNGQHPT; C1–C7: mutants by deletion; C8 and C9: mutants by substitution. WT, wild-type. Underlined sequence was mutated.