Table 1.
Invasive hemodynamics in PH with adaptive or maladaptive RV remodeling
| Pairwise Comparisons* |
|||||||
|---|---|---|---|---|---|---|---|
| Sham | PH-NF | PH-HF | P, ANOVA | Sham vs. PH-NF | Sham vs. PH-HF | PH-NF vs. PH-HF | |
| n | 4 | 12 | 8 | ||||
| Body weight, kg | 30.5 (29.5–31.3) | 29.0 (26.8–32.2) | 20.0 (17.5–22.5) | 0.0000007 | 0.67 | 0.00013 | 0.000013 |
| Hemodynamics | |||||||
| Heart rate, beats/min | 65 (53–76) | 73 (61–79) | 75 (72–86) | 0.17 | |||
| Mean aorta, mmHg | 96 (84–108) | 106 (83–126) | 75 (68–80) | 0.03 | 0.43 | 0.36 | 0.027 |
| Pressure, mmHg | |||||||
| Pulmonary artery wedge | 5 (4–6) | 12 (11–15) | 12 (11–14) | 0.005 | 0.007 | 0.007 | 0.94 |
| Mean pulmonary artery | 15 (13–15) | 28 (25–33) | 42 (29–47) | 0.0009 | 0.019 | 0.0007 | 0.03 |
| Right atrial | 2 (1–2) | 3 (3–4) | 3 (1–4) | 0.2 | |||
| Transpulmonary gradient, mmHg | 9 (8–10) | 14 (11–22) | 29 (27–33) | 0.014 | 0.12 | 0.015 | 0.09 |
| Cardiac index, l/min*m2 | 4.4 (4.1–4.7) | 4.7 (3.8–5.0) | 3.0 (2.8–4.2) | 0.056 | 0.056 | ||
| Stroke volume index, ml/m2 | 69 (62–77) | 64 (58–76) | 41 (39–46) | 0.007 | 0.58 | 0.019 | 0.016 |
| PVR index, wood units*m2 | 2.0 (1.7–2.3) | 3.0 (2.1–3.9) | 8.8 (6.8–12.3) | 0.004 | 0.21 | 0.008 | 0.02 |
| PVR-to-systematic vascular resistance ratio | 0.12 (0.11–0.13) | 0.18 (0.13–0.33) | 0.58 (0.43–0.59) | 0.001 | 0.18 | 0.003 | 0.006 |
| Pulmonary artery capacitance index, ml/mmHg*m2 | 5.7 (5.2–5.9) | 3.3 (2.6–3.8) | 1.7 (1.5–1.9) | 0.00001 | 0.0017 | 0.000012 | 0.0017 |
PH-NF, pulmonary hypertension, adaptive right ventricular (RV) remodeling, and no failure; PH-HF, pulmonary hypertension, maladaptive RV remodeling, and heart failure; PVR, pulmonary vascular resistance.
*
Presented if ANOVA P < 0.05.