Fig. 3.
Bar graphs comparing the effects of intratracheal injection of ASCs and ASCCOX-1 on pulmonary arterial pressure (A), systemic arterial pressure (B), cardiac output (C), and right heart mass (D) as measured by the Fulton Index {[RV/(LV + S)], where RV and LV are right and left ventricular and S is septum} in monocrotaline (MCT)-treated rats. *P < 0.05 ANOVA, Dunnett's test; n indicates number of animals. Mean pulmonary arterial pressure was increased significantly in MCT and MCT plus ASCs-treated animals. Mean pulmonary arterial pressure was decreased significantly in MCT plus ASCCOX-1-treated animals compared with MCT-treated rats. The right heart mass was increased significantly in MCT and MCT plus ASCs-treated animals compared with healthy controls. The right heart mass was decreased significantly in MCT plus ASCCOX-1-treated rats compared with MCT-treated animals.