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A: dose-dependent increases in GSK 101-mediated calcium influx in 4B cells. Mean maximum percent change in 340 nm-to-380 nm ratio from baseline are presented; the doses (nM) of GSK 101 are presented on X-axis: 1 nM (n = 4), 20 nM (n = 4), 50 nM (n = 3), 100 nM (n = 4), 200 nM (n = 4), 500 nM (n = 4). B: mean traces of calcium response after GSK 101 (100 nM) administration in cells incubated in control media and cells pretreated 10 μM HC 067047 and 125 μM CdCl2.
