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. 2014 Sep 25;15(9):17065–17076. doi: 10.3390/ijms150917065

Figure 4.

Figure 4

mTOR maybe act antagonistically with SMG1 to regulate cell growth. (A) Over-expression of mTOR in AML compared with controls confirmed by quantitative RT-PCR (p < 0.05); (B) Effect of SMG1 knockdown on mTOR mRNA expression in HEL cells. mTOR expression was increased in SMG1–siRNA-transfected group compared with the control–siRNA group confirmed by quantitative RT-PCR (*** p < 0.001); (C) DAC treatment decreased both mTOR and p-mTOR protein expression with dose-dependent effect confirmed by western blotting analysis; (D) mTOR and p-mTOR protein expression was increased in SMG1–siRNA-transfected group compared with the control–siRNA group confirmed by western blotting analysis.