Table 1. Clustered mutations in the UCS domain of the UNC45B proteins.

Species	Genea	Nucleotide change	Amino-acid change	Type of mutation	Inheritance	Consequenceb	Phenotype	Reference
X. tropicalis	Unc45b	c.2335T>C	p.Cys779Argc	Missense	Recessive	Damaging/lethal	Muscle	2
Zebrafish	unc45b	c.2364C>A	p.Cys788*,d	Nonsense	Recessive	Damaging/lethal	Muscle	10
C. elegans	unc-45	c.2341G>A	p.Glu781Lys	Missense	Recessive	Tolerant/paralyses	Muscle (ts)	30
C. elegans	unc-45	c.2464C>T	p.Leu822Phe	Missense	Recessive	Tolerant/paralyses	Muscle (ts)	30
Human	UNC45B	c.2413C>T	p.Arg805Trp	Missense	Dominant	Damaging	Cataract/lens	Present study

^aReferenced sequence accession numbers are given in Supplementary Information.

^bThe consequences of amino-acid changes are predicted by PolyPhen2.

^cThe Xenopus tropicalis Unc45b dicky ticker mutant.

^dThe zebrafish steif unc45b mutation.