Table 3. Factors associated with reduced participation in NBS using genome sequencing among willing participants of targeted NBS using current technologies (logistic regression).

	Unwilling to Participate in NBS using WG/ESa
Demographics
Age (reference: 55+)
18–35	−4.6 (3.3)
36–54	−0.9 (2.9)
Female	7.1 (2.5)**
Education (reference: post-secondary)
High school or less	−3.0 (3.4)
College/CEGEP	1.4 (3.0)
Income (reference: $80 000+)
Less than $40 000	1.1 (3.5)
$40 000-$79 999	−0.8 (3.1)
Married/common law	−3.7 (2.8)
Family history of disease	−5.2 (3.3)
Children	3.7 (.2.9)
Enthusiasm towards science and technology
Confidence in scienceb	−30.6 (8.6)***
Modern medicine can cure all (reference: disagree)
Neutral	−3.9 (3.3)
Agree	2.1 (2.8)
Importance in accessing most advanced procedures	−5.6 (3.6)
Trust in health carec
The government will ensure a high quality health care system (reference: disagree)
Neutral	−2.3 (3.3)
Agree	−7.9 (3.3)*
Governance of heath care
Decision on health care programmes should be left to experts	−1.8 (2.8)
Decisions on health care programmes should be based on scientific evidence about risks involved	−9.6 (2.9)***
Understanding of NBS & its effectsd
Awareness of NBS (reference: never heard about it)
Heard of it, but know nothing about it	1.8 (3.3)
Heard a little about it	2.1 (3.3)
Heard a lot about it	-1.3 (6.6)
Index of NBS understandinge	4.0 (0.8)***
N	918

Abbreviations: NBS, newborn screening; WG/ES, whole genome/exome sequencing.

Cell entries are average marginal effects (probabilities) translated into percentages with s.e.'s in parentheses. *P<0.05; **P<0.01; ***P<0.001.

Pseudo R²=0.13, Likelihood ratio test (LR(10)=112.33; P<0.001)

^aDependent variable=unwillingness to participate in NBS using WG/ES.

^bSelected items from the Eurobarometer's Social Values on Science and Technology Survey.³¹ ‘Confidence in science' index created (Alpha=0.70; 0-1 scale, mean=0.80, SD=0.16).

^cSelected item from a public trust in health care survey.²⁹

^dExposure to reasoning exercise included in model, but omitted from table (insignificant relationship).

^eIndex sums together the number of correct responses given to 21 questions (alpha=0.67).