Table 4. Factors associated with reduced parental responsibility to participate in NBS using genome sequencing among respondents who perceive a parental responsibility to participate targeted NBS using current technologies (logistic regression).

	Parents do not have a responsibility to participate in NBS using WG/ESa
Demographics
Age (Reference: 55+)
18–35	0.4 (6.0)
36–54	−6.4 (5.1)
Female	3.4 (4.5)
Education (Reference: post-secondary)
High school or less	−3.9 (5.6)
College/CEGEP	−1.4 (5.3)
Income (Reference: $80 000+)
Less than $40 000	−10.8 (6.2)+
$40 000–$79 999	−11.9 (5.4)*
Married/common law	−4.3 (4.9)
Family history of disease	−1.9 (5.5)
Children	−4.9 (5.1)
Enthusiasm towards science and technology
Confidence in scienceb	−58.0 (15.9)***
Modern medicine can cure all (reference: disagree)
Neutral	−3.5 (5.8)
Agree	−6.2 (5.0)
Importance in accessing most advanced procedures	2.3 (8.7)
Trust in health carec
The government will ensure a high quality health care system (reference: disagree)
Neutral	6.1 (7.0)
Agree	−4.8 (6.4)
Governance of heath care
Decision on health care programmes should be left to experts	−0.8 (5.6)
Decisions on health care programmes should be based on scientific evidence about risks involved	−5.2 (6.8)
Understanding of NBS and its effectsd
Awareness of NBS (reference: never heard about it)
Heard of it, but know nothing about it	14.3 (5.7)*
Heard a little about it	17.3 (5.7)**
Heard a lot about it	32.2 (11.1)**
Index of NBS understandinge	4.8 (1.0)***
N	472

Abbreviations: NBS, newborn screening; WG/ES, whole genome/exome sequencing.

Cell entries are average marginal effects (probabilities) translated into percentages with standard errors in parentheses. *P<0.05; **P<0.01; ***P<0.001.

Pseudo R²=0.14, likelihood ratio test (LR(10)=92.75; P<0.001).

^aDependent variable=Belief that parents do not have a responsibility to participate in NBS using WG/ES.

^b‘Confidence in science' index created based on selected items from the Eurobarometer's Social Values on Science and Technology Survey.³¹ (alpha=0.70; 0–1 scale, mean=0.80, SD=0.16).

^cSelected item from a public trust in health care survey.²⁹

^dExposure to reasoning exercise included in model, but omitted from table (insignificant relationship).

^eIndex sums together the number of correct responses given to 21 questions (alpha=0.67).