Table 1.

Validated targets of miRNAs implicated in the pathophysiology of cardiovascular disease. What is evident from this table is that multiple gene targets are targeted by multiple miRNAs under a variety of pathological conditions.

miRNA	Gene targets	Pathophysiology	Ref(s).
Let7	Nf2	INFR, Cancer	250
1	RhoA, Cdc42, Nelf-A/WHSC2, Kcnj2, Gja1, Ppp2r5a, Vegfa	CH, ARR, ANG	81, 82, 106, 151
10	MAP3K7, βTRC, Flt1	ATH, ANG	122, 154
15	Vegfa	ANG	149
16	Kdr	ANG	155
20	Vegfa, Hif1a	ANG	150
21	Pten, Pdcd4, Ppara, Mpv17l, Sorbs2, Pdlim5	Cancer, ISC, INFR, CH	64, 65, 123, 165, 166, 253
23	Xiap, MuRF1	CI, CH	95, 261
25	Serca2, Ip3r1	ARR, HF	83
26	Kcnj2	ARR	90
29	Adamts7, Col1a1, Col1a2, Col3a1, Fibrillin	ATH, ARR, CR	56, 57, 169
30	CTGF, MTP	CR, ATH, DLD	54, 182
33	CROT, CPT1a, HADHB, AMPKa, IRS2, ABCA1, Npc1	ATH, DLD	179, 180, 183
34	Ppp1r10, vinculin, Sema4b, Pofut1, Bcl6	MI, CH	52, 53
93	Vegfa	MetS	153
122	Slc7a1, Agpat1, Alpl, Cs, Klf6, Prom1, Sox4	Cancer, DLD	185, 186, 217
125	Grin2a	NSP	273
126	Spred1, Vcam1, Rgs16, Foxo3, Bcl2, Irs1, Tsc1	ANG, ATH, INFR	130, 133, 134, 135, 157, 159
130	Pparg	MetS	291
132	FoxO3, p300, p120RasGAP, MeCP2	CH, INFR, ANG, Rett Syndrome	102, 137, 138, 139
133	CTGF, RhoA, Cdc42, Nelf-A/WHSC2	CH, CR	54, 106
143	Klf5, Ssh2, Mrtfb, Orp8	ATH, T2DM	128, 302
144	ABCA1	DLD	181
145	Klf4, Klf5, Srgap1/2, Ssh2, Ace	ATH	127, 128, 129
146	Tlr4, Myd88, Irak1, Traf6	INFR	251
155	Jarid2, Bcl6, eNOS, Socs1, c-MAF, Tnf	CH, ATH, HT, INFR	96, 99, 100, 101, 160, 211
181	Cyld, Gria2	Cancer, NSP	253, 274
192	Sip1	CR	51
199	Dyrk1a	CH	93
200	Vegfa	Diabetic Retinopathy	152
204	Mafa	T1DM	299
208	Med13	CH, MetS	67, 68, 287
206	Vegfa	ANG	151
210	Gpd1l, Efna3, Ptp1b, Rad52, E2f3, Casp8ap2, Iscu	HYP, cMet	230, 231, 232, 233, 234, 235, 236
212	FoxO3	CH	102
214	Slc8a1, Bcl2l11, Ppif	CR	80
221/222	p27kip1	ATH	168
223	Icam1, Gria2, Grin2b, Pknox1	ATH, CI, MetS	176, 275, 290
296	Hgs	ANG	156
301	Pias3	INFR	252
320	Aqp1, Aqp4, Hsp6b, Ets2, Mmp9, Emilin2, Nrp1, Pfkm	CI, MI/ISC, Cancer, ANG, cMet	265, 266, 268, 269, 270
328	Pim1, Cacna1c, Cacnb1, Igf1r	Cancer, ARR, HYP	84, 239, 249
342	Akt1, Bmpr2	ATH	161
375	Cadm1, Gphn, Cav1, Id3, Smarca2, Rasd1, Aifm1, Mtpn, Vti1a	T1DM	294, 298
378	Med13, Crat	DLD, MetS	286
380	Tp53	Cancer	78
424	Cul2	HYP, ANG	228
425	Nppa	HT	222
484	Fis1	HYP, cMet	77
486	Pten, Foxo1a	CH	158
499	Calcineurin, Drp1, Sox6, Purβ, Sp3, Hp-1β, Med13, Mstn, Mapk6	CH, Striated Muscle Performance	35, 73, 74
637	ATP6VOA1	HT	218

Arrhythmia – ARR, Atherosclerosis – ATH, Angiogenesis – ANG, Cardiac Hypertrophy – CH, Cerebral Infarct – CI, Cardiac Remodeling – CR, Cellular Metabolism – cMet, Dyslipidemia – DLD, Heart Failure – HF, Hypertension – HT, Hypoxia – HYP, Inflammation and Immune Response – INFR, Ischemia – ISC, Metabolic Syndrome – MetS, Myocardial Infarction – MI, Neuronal and Synaptic Plasticity – NSP, Type 1 Diabetes – T1DM, Type 2 Diabetes – T2DM.