Figure 1.

The N400 to new words (congruous and incongruous targets separately, measured from 300–550 ms time window as illustrated on the right Wernicke's channel) at six electrodes from fronto-central (FC1/2, Cz), temporal (WL/WR), and parietal (Pz) scalp sites, plotted by treatment group and visits. The memantine group showed an insignificant increase in N400 congruity effect amplitude (new incongruous−congruous words, Baseline=−0.83±1.96 μV, 1 year=−1.46±2.01; p=0.11) after 1 year of treatment, whereas the placebo group displayed an insignificant reduction over the period (Baseline=−0.86±2.25 μV, 1 year=−0.43±1.77; p=0.31).