Table 2. Effect of Alpha-Methyl-Para-Tyrosine (AMPT) on Self-Reported Measures (n=10).
| Scales | Baseline scores | AMPT 5 h scores | AMPT 27 h scores | %Δ Scores over 27 h | P-value | FDR P Threshold |
|---|---|---|---|---|---|---|
| Profile of mood states (POMS) | ||||||
| Fatigue | 9.6 (3.6) | 10.4 (3.7) | 15.4 (6. 1) | +66.4 | 0.0068a | 0.008 |
| Vigor | 25.7 (9.2) | 23.4 (5.9) | 19.4 (7.1) | −21.8 | 0.0046a | 0.017 |
| Tension | 11.1 (2.3) | 11.9 (3.3) | 13 (4.5) | +15.5 | 0.0463 | 0.025 |
| Depression | 16.3 (3.1) | 16.0 (3.1) | 18.9 (7.9) | +13.4 | 0.1817 | 0.033 |
| Confusion | 11.9 (2.1) | 11.7 (2.3) | 13.3 (4.7) | +11.6 | 0.2606 | 0.042 |
| Anger | 12.5 (1.1) | 13 (2.0) | 13.8 (4.8) | +9.3 | 0.3464 | 0.050 |
| Subjective well-being under neuroleptic treatment (SWN) | ||||||
| Physical functioning | 22.2 (1.5) | 22 (1.6) | 19.9 (2.8) | −10.5 | 0.0094 | 0.007 |
| Negative sum | 57.7 (2.3) | 56.9 (3.0) | 54.2 (4.4) | −6.10 | 0.0105a | 0.014 |
| Emotion egulation | 22.4 (1.3) | 21.8 (1.8) | 21 (2.5) | −6.36 | 0.0498 | 0.021 |
| Mental functioning | 22 (1.6) | 21.7 (2.1) | 20.3 (3.2) | −7.91 | 0.0523 | 0.029 |
| Positive sum | 52.6 (5.5) | 51.5 (6.1) | 48.3 (10.8) | −8.88 | 0.0867 | 0.036 |
| Self-control | 22.3 (1.4) | 22.2 (1.4) | 20.9 (3.8) | −6.58 | 0.1914 | 0.043 |
| Social integration | 21.4 (2) | 20.7 (2.4) | 20.4 (3.2) | −4.71 | 0.2289 | 0.050 |
Abbreviation: FDR, false discovery rate.
Data are given as mean raw scores with SD in parenthesis.
a
Denotes significance after FDR correction.