Figure 5.

Effect of NAc core flupenthixol on context-induced renewal of cocaine seeking. Experiment 4. Mean (±SEM) number of responses made in a single 2-h renewal test session in the cocaine training context for STs and GTs that had been extinguished in either the cocaine training context (COC groups) or a novel, alternate context (ALT groups), and that had received either vehicle (VEH groups) or flupenthixol (15 μg; FLU groups) before the session. Group sizes are: GT-COC-VEH (n=7), GT-COC-FLU (n=7), GT-ALT-VEH (n=8), GT-ALT-FLU (n=7), ST-COC-VEH (n=5), ST-COC-FLU (n=4), ST-ALT-VEH (n=8), and ST-ALT-FLU (n=8). All groups were tested for renewal in the cocaine training context. Bars represent active nose pokes and dotted lines represent inactive nose pokes. *p<0.05; **p<0.01; ***p<0.001.