Figure 1.

(a) MR slices from rhesus monkey in transverse, sagittal, and coronal orientations. (b) Registered PET images in the control study following bolus injection of [11C]GSK931145. (c) Matching images following administration of 0.5 mg/kg Org 25935. PET images are on a common SUV scale (corrected for injection dose and body weight). Blockade of specific binding is visible by increased uniformity in the blocking scans. The activity concentration at the level of the midbrain (arrows) is not detected after Org 25935 administration.