Table 2.
Clinical trials of low-dose vasopressin in vasodilatory shock states
| Reference | Year | Trial | n | Patients | Findings |
| [4] | 1997 | Case series | 5 | Septic shock | A, B, C |
| [3] | 1997 | Matched cohort | 19 | Septic shock | A, B, D in septic group |
| 12 | Cardiogenic shock | ||||
| [5] | 1999 | RCT | 10 | Septic shock – trauma | A, B |
| [2] | 2000 | RCT | 24 | Septic shock | A, B, C, D |
| [94] | 2001 | Retrospective | 60 | Septic and postcardiotomy shock | A, B, ↓ CI |
| [95] | 2001 | Prospective, case-controlled | 16 | Septic shock | A, B, C |
| [7] | 1998 | Retrospective case series | 40 | Postbypass vasodilatory shock | A, B, D |
| [6] | 1997 | RCT Placebo: N/S | 10 | Vasodilatory shock post-LVAD implant | A, B in treatment arm; D in all |
| [8] | 1999 | Case series | 20 | Vasodilatory shock post-cardiac transplant | A, B |
| [9] | 1999 | Case series | 11 | Pediatric – vasodilatory shock postbypass | A, B, D |
| [10] | 2000 | Retrospective case series | 50 | Vasodilatory shock post-LVAD implantation | A, B |
| [69] | 2002 | Retrospective | 41 | Postcardiotomy shock | A, B |
| [11] | 1999 | Case series | 10 | Organ donors with vasodilatory shock A, D | |
| [68] | 2000 | Case series | 7 | Milrinone – hypotension | A, B, C |
Findings are classified as follows: A, increase in blood pressure; B, decrease or discontinuance of catecholamines; C, increase in urine output; and D, low plasma vasopressin levels in subjects. CI, cardiac index; LVAD, left ventricular assist device; N/S, normal saline; RCT, randomized controlled trial.