Table 1.
Summary of Demographic Characteristics
| Variables | Placebo | Naltrexone 192 mg | Naltrexone 384 mg | All | P-Values1 | |
|---|---|---|---|---|---|---|
|
| ||||||
| (N=18) | (N=20) | (N=22) | (N=60) | |||
| SEX | Male | 12 (67%) | 15 (75%) | 19 (86%) | 46 (77%) | 0.380 |
| Female | 6 (33%) | 5 (25%) | 3 (14%) | 14 (24%) | ||
|
| ||||||
| RACE | White | 7 (39%) | 7 (35%) | 8 (37%) | 21 (37%) | 0.342 |
| Black | 7 (39%) | 5 (25%) | 9 (41%) | 21 (35%) | ||
| Hispanic | 3 (17%) | 5 (25%) | 3 (14%) | 11 (18%) | ||
| Asian | 0 (0%) | 0 (0%) | 2 (9%) | 2 (3%) | ||
| Other | 1 (6%) | 3 (15%) | 0 (0%) | 4 (7%) | ||
|
| ||||||
| AGE (years) | 18 – 30 | 3 (17%) | 4 (20%) | 4 (18%) | 11 (18%) | 0.849 |
| 30 – 59 | 15 (83%) | 15 (80%) | 18 (82%) | 49 (82%) | ||
| Mean (SD) | 40 (11) | 42 (10) | 41 (11) | 41 (10) | ||
| Range | 20 – 59 | 26 – 59 | 19 – 56 | 19 – 59 | ||
|
| ||||||
| HEROIN USE | ||||||
| Lifetime (Years) | Mean (SD) | 15.1 (11.8) | 15.7 (12.0) | 10.7 (9.8) | 13.7 (11.1) | 0.385 |
| Past Month (Days) | Mean (SD) | 29.3 (2.6) | 28.7 (4.6) | 24.4 (2.4) | 29.2 (3.2) | 0.903 |
|
| ||||||
| METHADONE USE | ||||||
| Lifetime (Years) | Mean (SD) | 1.5 (3.3) | 1.1 (1.2) | 3.0 (6.2) | 1.9 (4.3) | 0.256 |
| Past Month (Days) | Mean (SD) | 0.9 (1.8) | 0.1 (0.4) | 0.2 (0.5) | 0.4 (1.1) | 0.137 |
|
| ||||||
| OTHER OPIOID USE | ||||||
| Lifetime (Years) | Mean (SD) | 0.0 (0.1) | 0.8 (2.6) | 1.9 (7.8) | 1.0 (5.0) | 0.557 |
| Past Month (Days) | Mean (SD) | 0.1 (0.3) | 0.3 (1.0) | 0.4 (1.2) | 0.3 (1.0) | 0.631 |
|
| ||||||
| BARBITURATE USE | ||||||
| Lifetime (Years) | Mean (SD) | 0.0 (0.0) | 0.0 (0.0) | 0.1 (0.2) | 0.0 (0.1) | 0.155 |
| Past Month (Days) | Mean (SD) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | - |
|
| ||||||
| OTHER SEDATIVE USE | ||||||
| Lifetime (Years) | Mean (SD) | 0.1 (0.5) | 0.3 (0.9) | 0.3 (1.0) | 0.3 (0.8) | 0.944 |
| Past Month (Days) | Mean (SD) | 0.2 (0.8) | 1.4 (3.8) | 0.5 (1.3) | 0.7 (2.3) | 0.297 |
|
| ||||||
| COCAINE USE | ||||||
| Lifetime (Years) | Mean (SD) | 4.4 (5.5) | 4.8 (8.6) | 3.6 (6.6) | 4.2 (6.9) | 0.803 |
| Past Month (Days) | Mean (SD) | 3.1 (5.7) | 2.1 (4.5) | 1.3 (2.4) | 2.1 (4.3) | 0.537 |
|
| ||||||
| ALCOHOL USE | ||||||
| Lifetime (Years) | Mean (SD) | 2.0 (4.1) | 0.3 (1.0) | 2.3 (6.0) | 1.6 (4.4) | 0.769 |
| Past Month (Days) | Mean (SD) | 0.1 (0.3) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.1) | 0.997 |
|
| ||||||
| CANNABIS USE | ||||||
| Lifetime (Years) | Mean (SD) | 5.5 (8.9) | 9.2 (13.2) | 9.8 (11.3) | 8.3 (11.2) | 0.505 |
| Past Month (Days) | Mean (SD) | 3.5 (8.1) | 4.1 (8.8) | 2.4 (5.8) | 3.3 (7.5) | 0.777 |
1
P-values for comparisons of the distributions of gender and race among treatment groups are based on the Cochran-Mantel-Haenszel (general association) stratified by center. P-values for comparisons of the distributions of age, height, weight and drug use among treatment groups are based on a two-way ANOVA model containing the effect of treatment and center.