Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT	100 women with mastalgia	Mean Cardiff Breast pain Score (CBS score 1–4), where CBS 1 is 'an excellent response leaving no pain' and CBS 4 is 'no response' 7 days 1.92 with topical diclofenac 2.16 with oral diclofenac	P = 0.56		Not significant
RCT	100 women with mastalgia	Response rate (percentage of women with no pain or some residual pain which is considered 'bearable') 7 days 39/50 (78%) with topical diclofenac 31/50 (62%) with oral diclofenac	Significance not assessed
RCT	100 women with mastalgia	Response rate (percentage of women with no pain or some residual pain which is considered 'bearable') 30 days 36/40 (90%) with topical diclofenac 32/36 (88.9%) with oral diclofenac	Significance not assessed
RCT	100 women with mastalgia	Response rate (percentage of women with no pain or some residual pain which is considered 'bearable') 90 days 19/20 (95%) with topical diclofenac 18/18 (100%) with oral diclofenac	Significance not assessed