Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT 3-armed trial	93 women with severe cyclical mastalgia	Proportion of women with >50% pain relief at the end of 6 months' treatment 21/32 (66%) with danazol 11/29 (38%) with placebo	P <0.01	Effect size not calculated	danazol
RCT 3-armed trial	93 women with severe cyclical mastalgia	Proportion of women with >50% pain relief 12 months after the 6 months of treatment 12/32 (38%) with danazol 0/29 (0%) with placebo	P <0.001	Effect size not calculated	danazol