Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	147 pre-menopausal women with breast pain	Vaginal dryness 22% with goserelin injection 13% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Hot flushes 58% with goserelin injection 16% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Decreased libido 28% with goserelin injection 7% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Oily hair or skin 18% with goserelin injection 9% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Breast size reduction 16% with goserelin injection 9% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Irritability 24% with goserelin injection 17% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Depression 16% with goserelin injection 18% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Tension 18% with goserelin injection 20% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Headache 50% with goserelin injection 52% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Hirsutism 4% with goserelin injection 0% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Acne 14% with goserelin injection 11% with placebo injection	Significance not reported
RCT	147 pre-menopausal women with breast pain	Ankle oedema 14% with goserelin injection 22% with placebo injection	Significance not reported