Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT	60 pre-menopausal women with cyclical breast pain	Proportion of women with >50% reduction in mean pain score (measured by visual analogue scale) 3 months 22/31 (71%) with tamoxifen 20 mg daily 11/29 (38%) with placebo	P <0.03	Effect size not calculated	tamoxifen
RCT 3-armed trial	93 women	Proportion of women with >50% reduction in mean pain score at the end of 6 months' treatment 23/32 (72%) with tamoxifen 10 mg daily 11/29 (38%) with placebo	P = 0.04 Results were also significant 6 and 12 months after the end of treatment	Effect size not calculated	tamoxifen
RCT	88 women aged 22 to 44 years	Proportion of women who achieved complete recovery (outcome not clearly defined) 8 months 40/44 (90%) with tamoxifen 0/44 (0%) with placebo	P value not reported