Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	60 pre-menopausal women with cyclical breast pain	Hot flushes 8/31 (26%) with tamoxifen 20 mg daily 3/29 (10%) with placebo	Reported as not significant		Not significant
RCT	60 pre-menopausal women with cyclical breast pain	Vaginal discharge 5/31 (16%) with tamoxifen 20 mg daily 2/29 (7%) with placebo	Reported as not significant		Not significant
RCT 3-armed trial	93 women	Hot flushes 8/32 (25%) with tamoxifen 10 mg daily 3/29 (10%) with placebo	P value not reported
RCT 3-armed trial	93 women	Vaginal discharge 5/32 (16%) with tamoxifen 10 mg daily 2/29 (7%) with placebo	P value not reported
RCT	88 women aged 22 to 44 years	Adverse effects with tamoxifen with placebo