Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT	301 women with cyclical breast pain for >6 months	Pain relief (reduction of 2 points on pain score) 3 months 127/155 (82%) with 10 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months 107/142 (75%) with 20 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months	P value reported as not significant		Not significant
RCT	60 women with cyclical and non-cyclical mastalgia	Response rates 3 months 12/14 (86%) with 10 mg daily doses of tamoxifen 11/13 (85%) with 20 mg daily doses of tamoxifen	P value not reported but stated as not significant		Not significant
RCT	60 women with cyclical and non-cyclical mastalgia	Response rates 6 months 14/15 (93%) with 10 mg daily doses of tamoxifen 13/15 (87%) with 20 mg daily doses of tamoxifen	P value not reported but stated as not significant		Not significant